Models | Estimate Transition /Transversion Bias (ML)
This option estimates the Transition /Transversion bias parameters κ, κ1, and κ2 using the Maximum Likelihood method. κ is used as a parameter of the Kimura Two-Parameter model of nucleotide evolution and some others, while κ1 and κ2 are used by the Tamura-Nei 93 model. This is applicable only to nucleotide data (coding or non-coding).